Which of the following conditions may increase the risk of seizures when taking bupropion?

Bupropion is an antidepressant that is known to lower the seizure threshold in certain individuals. A relevant risk factor for seizures when using this medication is a history of head injuries. Head injuries can cause structural changes in the brain, which may predispose a person to seizures, particularly when combined with substances that are known to lower the seizure threshold.

While major depressive disorder, generalized anxiety disorder, and chronic pain syndromes can all provide context for why someone may be prescribed bupropion, they do not inherently increase the likelihood of seizures as a direct effect of the condition itself. In contrast, head injuries represent a direct alteration of brain function that can lead to seizure activity, making this condition particularly significant when evaluating the safety of bupropion use.