Which medication is effective for treating pain during an acute exacerbation of gout?

Indomethacin (Indocin) is a nonsteroidal anti-inflammatory drug (NSAID) that is particularly effective for managing pain and inflammation during an acute gout attack. Gout is characterized by sudden, intense episodes of pain due to the crystallization of uric acid in the joints. Indomethacin works by inhibiting the production of prostaglandins, which play a key role in causing inflammation and pain.

In the context of treating an acute exacerbation of gout, the use of NSAIDs like indomethacin is well-supported by clinical practice due to their rapid onset of action and effectiveness in reducing inflammatory pain. This makes them preferable during acute episodes rather than other options, which may not address the immediate pain relief required.

Acetaminophen does not provide the anti-inflammatory effects needed in this situation, while systemic steroids may be used if NSAIDs are contraindicated, but they are not the first line for acute attacks. Allopurinol, while helpful in managing chronic gout and preventing future attacks by lowering uric acid levels, is not indicated for the acute management of a gout flare and may even exacerbate symptoms if started during an acute episode. Thus, indomethacin stands out as the appropriate choice for