Which condition is associated with thyroid hypofunction?

Myxedema is indeed associated with thyroid hypofunction, specifically referring to severe or advanced hypothyroidism. In this condition, the thyroid gland fails to produce adequate amounts of thyroid hormones (primarily thyroxine). This deficiency can lead to various symptoms, including fatigue, weight gain, cold intolerance, and hair loss. Myxedema is characterized by the accumulation of mucopolysaccharides in connective tissues, leading to changes in the skin and other tissues, such as swelling and a puffy appearance.

On the other hand, Graves disease is an autoimmune disorder characterized by hyperthyroidism, which involves the overproduction of thyroid hormones. Eye disorders associated with Graves disease, often referred to as Graves' ophthalmopathy, are related to hyperthyroid conditions rather than hypofunction. Thyroid storm is a life-threatening condition resulting from exacerbated hyperthyroidism, with severe symptoms including fever, tachycardia, and altered mental status. Therefore, myxedema emphasizes the symptoms and consequences of inadequate thyroid hormone levels, making it the condition directly associated with thyroid hypofunction.