Which class of drugs is most likely to cause sexual dysfunction in males?

Selective serotonin reuptake inhibitors (SSRIs) are known to be the class of drugs most likely to cause sexual dysfunction in males. The mechanism by which SSRIs cause these side effects is primarily related to their action on serotonin levels in the brain. By increasing serotonin availability, SSRIs can inhibit sexual arousal and performance.

Common reports of sexual dysfunction associated with SSRIs include erectile dysfunction, delayed ejaculation, and reduced libido. This side effect is particularly significant in clinical practice, as it can affect medication adherence among patients with depression or anxiety who have been prescribed these medications.

In contrast, other classes of drugs listed do not have the same well-documented association with sexual side effects. ACE inhibitors, while used primarily for hypertension and heart failure, generally do not have sexual dysfunction as a common side effect. Amphetamines can increase libido but are not typically associated with sexual dysfunction. Atypical antidepressants vary in their profiles but are often chosen specifically for their lower risk of sexual side effects compared to traditional SSRIs.

Given this information, SSRIs stand out as the class that is most likely to lead to sexual dysfunction, making them critical to consider in both prescribing practices and when addressing patient concerns about sexual health.