Which benzodiazepine has the shortest half-life?

Triazolam, known by the brand name Halcion, is the benzodiazepine with the shortest half-life among the options listed. The half-life of triazolam ranges from about 1.5 to 5.5 hours, which makes it particularly short-acting compared to the other benzodiazepines listed. This short duration of action can make triazolam useful for patients who suffer from insomnia, as it typically helps them fall asleep quickly without lingering effects the next day.

The pharmacokinetics of triazolam contribute to its rapid onset and quick elimination from the body, which is a key characteristic that sets it apart from other benzodiazepines like lorazepam, alprazolam, and clonazepam, all of which have longer half-lives. Understanding the half-life of medications is crucial in managing their use effectively, especially in treating conditions like anxiety and sleep disorders, where timing and duration of effects are significant for patient care.