Which antihypertensive drug class has the largest amount of research studies supporting its use?

Thiazide diuretics have been widely studied and have a substantial body of evidence supporting their effectiveness in managing hypertension. They are often recommended as first-line treatment options for essential hypertension, particularly in the general population and older adults. The extensive research has demonstrated their ability to reduce cardiovascular morbidity and mortality, which has solidified their position in clinical practice guidelines.

Additionally, thiazide diuretics are known for their efficacy in lowering blood pressure, beneficial effects on cardiovascular outcomes, and relatively low cost. They work by promoting the excretion of sodium and water from the kidneys, which leads to a reduction in blood volume and subsequently lowers blood pressure.

While the other classes of antihypertensives—ACE inhibitors, ARBs, and calcium channel blockers—are also backed by significant research, thiazide diuretics stand out due to the volume and depth of studies that support their use across various populations and clinical settings.