What is a common side effect seen in women using Depo-Provera for over 5 years?

Amenorrhea is a well-documented side effect associated with the use of Depo-Provera (medroxyprogesterone acetate), particularly in women who have been using it for extended periods, such as over 5 years. Depo-Provera works as a form of contraceptive by inhibiting ovulation and altering the endometrial lining, which can lead to a significant reduction or complete cessation of menstrual periods for many users.

Over time, the hormonal effects of the injection can result in amenorrhea, as the body becomes adapted to the contraceptive's influence on the reproductive system. This is a particularly common occurrence and is considered a normal side effect of long-term use.

Understanding this side effect is critical for health care providers when counseling patients about the potential risks and benefits of Depo-Provera, allowing for informed decision-making regarding contraception.